The Southern Plant Diagnostic Network (SPDN) is a partnership of 14 states and territories in the southeast US functioning as a cohesive, distributed system to quickly detect pests and pathogens in our agricultural and natural ecosystems, serving a wide array of public and private clientele. Our goal is to (i) support a secure regional network for the detection and diagnosis of plant health problems, (ii) extend and support sound public policies, implement rapid and accurate diagnoses, and response strategies, and (iii) provide leadership and training.